''Griffin's Way'' is set in Mississippi during the turbulent Reconstruction era following the American Civil War. The narrative centers on Paris Griffin, a young Southern aristocrat who returns to his family's Mississippi plantation after losing his memory during the Civil War. Desperate to break through his psychological blackness, his brother hires a nurse named Candace Trevor. As Candace successfully guides Paris back to reality, the two deeply fall in love. However, their romance is fiercely complicated by the fact that both are already married to other people—Paris to his unfaithful wife Laurie—and bound by rigid social vows they struggle to break. The novel vividly captures the onset of the Ku Klux Klan's campaign of white supremacist terror in post-war Mississippi. The local Grand Dragon, Di Cadwallader, drives a murderous campaign against racial equality, targeting anyone—including liberal white citizens—who opposes them. Similar to Yerby's debut novel The Foxes of Harrow, the titular estate "Griffin's Way" is presented as a beautiful facade that hides the messy, horrific realities of slavery and exploitation that built it. Rather than romanticizing the Old South, Yerby uses the setting to expose the psychological scars of the war, the deep-seated racism of the region, and the moral corruption affecting both white and Black characters navigating the collapse of the old social order.