Adrenal disorders are often difficult to diagnose due to common symptoms, and challenging to treat due to common comorbidities. Adrenal Disorders: 100 Cases from the Adrenal Clinic provides a comprehensive, case-based approach to the evaluation and treatment of both common and uncommon adrenal disorders, offering practical, real-world guidance highlighted by detailed laboratory evaluations, computed cross sectional images, nuclear medicine images, and gross pathology photographs.

Section A. Incidentally Discovered Adrenal Mass Case #1: 45-Year Old Woman with an Incidentally Discovered Large Adrenal Mass Case #2: Adrenal Mass in a Patient with History of Extra-adrenal Malignancy: the Role of Imaging Case #3: Incidentally Discovered Adrenal Mass in a Patient with History of Extra-adrenal Malignancy: the Role of Adrenal Biopsy Case #4: Nonfunctioning Lipid Rich Adrenocortical Adenoma—Role of Follow-up Case #5: 54-Year Old Woman with an Incidentally Discovered Adrenal Mass and Abnormal Dexamethasone Suppression Test: Role of Adrenalectomy Case #6: Lipid Poor Adrenal Masses—The Case for Aggressive Management Section B. Primary Aldosteronism Case #7: Primary Aldosteronism—When Adrenal Venous Sampling is not Needed Before Unilateral Adrenalectomy Case #8: Primary Aldosteronism with Unilateral Adrenal Nodule on Computed Tomography Case #9: Primary Aldosteronism with Bilateral Adrenal Nodules on Computed Tomography Case #10: Primary Aldosteronism Caused by Unilateral Adrenal Hyperplasia Case #11: Primary Aldosteronism in a Patient with Bilateral Macronodular Adrenal Hyperplasia and Associated Clinically Important Cortisol Co-secretion Case #12: Primary Aldosteronism in a Patient with an Adrenal Macroadenoma and Clinically Important Cortisol Co-secretion Case #13: Primary Aldosteronism in a Patient Treated with Spironolactone Case #14: Failed Catheterization of the Right Adrenal Vein—When Incomplete Adrenal Venous Sampling Data Can Be Used to Direct a Surgical Cure Case #15: Primary Aldosteronism: When Adrenal Venous Sampling Shows Suppressed Aldosterone Secretion From Both Adrenal Glands

Section C. ACTH-Independent Cushing Syndrome Case #16: 28-Year-Old Woman with Remote History of Adrenal Mass Presenting with New Onset Hypertension and Weight Gain Case #17: 26-Year-Old Woman with a Discrepant Work-up for Cushing Syndrome Subtype Case #18: 45-Year-Old Woman with Corticotropin-Independent Cushing Syndrome and Bilateral Adrenal Adenomas Case #19: Corticotropin-Independent Cushing Syndrome in a Patient with “Normal” Adrenal Imaging Case #20: 66-Year-Old Woman with Corticotropin-Independent Hypercortisolism and Bilateral Macronodular Adrenal Hyperplasia Case #21: 35-Year-Old Woman with Low Bone Density and Fractures Case #22: Carney Triad (Pentad) and Adrenal Adenoma with Clinically Important Cortisol Secretory Autonomy  

Section D. Adrenal Cortical Carcinoma and Oncocytic Neoplasm Case #23: Adrenal cortical carcinoma in a patient with history of adrenal incidentaloma Case #24: Unexpected Diagnosis of Adrenal Cortical Carcinoma: Role of Urinary Steroid Profiling Case #25: Oncocytic adrenocortical carcinoma Case #26: Mitotane therapy in the ENSAT Stage II Adrenocortical Carcinoma Case #27: Cortisol-Secreting Metastatic Adrenocortical Carcinoma—Role for Surgical Debulking of the Primary Tumor Case #28: Adrenocortical Carcinoma and Severe Cushing Syndrome Case #29: Pure Aldosterone-Secreting Adrenocortical Carcinoma Case #30: Long-standing Primary Aldosteronism in a Patient Diagnosed with Metastatic Adrenocortical Carcinoma Case #31: Adrenocortical Carcinoma Associated with Lynch Syndrome Case #32: Adrenocortical Carcinoma Associated with Multiple Endocrine Neoplasia Type 1 Case #33: Adrenocortical Carcinoma Presenting with Inferior Vena Cava Thrombus Case #34: Management of Mitotane Therapy in Adrenocortical Carcinoma

Section E. Pheochromocytoma and Paraganglioma Case #35: Most Pheochromocytomas Grow Slowly Case #36: The “Prebiochemical” Pheochromocytoma Case #37: Huge Catecholamine-Secreting Tumor Case#38: Metyrosine Use in a Patient with Metastatic Pheochromocytoma Case #39: Pheochromocytoma in a Patient with Neurofibromatosis Type 1 Case #40: New Diagnosis of Multiple Endocrine Neoplasia Type 2A in a Patient with Bilateral Pheochromocytomas Case #41: Pheochromocytoma in a Patient with von Hippel Lindau Disease Case #42: Bilateral Pheochromocytoma in a Patient with MYC-associated Protein X (MAX) Genetic Predisposition Case #43: The Cystic Pheochromocytoma Case #44: Skull Base and Neck Paragangliomas—Considerations for the Endocrinologist Case #45: Cardiac Paraganglioma. Case #46: Pheochromocytoma in Multiple Endocrine Neoplasia Type 2B Case #47: Metastatic Paraganglioma—An Approach to Management and the Use Serial Imaging to Assess Rate of Tumor Progression Case #48: Metastatic Pheochromocytoma—Role for 68-Ga DOTATATE PET CT Case #49: Carney Triad (Pentad) and Catecholamine-Secreting Paragangliomas Case #50: Metastatic Paraganglioma—Role For Systemic Chemotherapy Case #51: Cryoablation Therapy for Metastatic Paraganglioma Case #52: Paraganglioma in a patient with cyanotic cardiac disease Case #53: Metastatic Paraganglioma—Role For External Beam Radiation Therapy  

Section F. Corticotropin (ACTH)-Dependent Hypercortisolism Case #54:ACTH-Dependent Cushing Syndrome can be frequently misdiagnosed Case #55: ACTH-Dependent Cushing Syndrome—Role for Inferior Petrosal Sinus Sampling Case #56: ACTH-Dependent Cushing Syndrome—When Inferior Petrosal Sinus Sampling is Not Needed Case #57: Severe ACTH-Dependent Cushing Syndrome Due to a Pituitary Adenoma Ectopic Cushing Syndrome Associated with Multiple Endocrine Neoplasia Type 2B Case #59: Ectopic Cushing Syndrome Treated with Cryoablation  Case #60: Cyclical Ectopic Cushing Syndrome Case #61: Mild Cushing Syndrome Associated with Ectopic Corticotropin Secretion Case #62: Bilateral Adrenal Cryoablation in Corticotropin-dependent Cushing Syndrome Case #63: Cushing Syndrome Associated with Ectopic Corticotropin and Corticotropin Releasing Hormone Secreting Pheochromocytoma Case #64: Cushing Syndrome in the Setting of Multiple Endocrine Neoplasia Type 1

Section G. Other Adrenal Masses Case #65: Adrenal Myelolipoma—A Computed Tomography Diagnosis Case #66: Adrenal Schwannoma Case #67: Trauma-Related Unilateral Adrenal Hemorrhage Case #68: Bilateral Adrenal Hemorrhage Case #69: Primary Adrenal Teratoma Case #70: The Adrenal Stone Case #71: Simple Adrenal Cyst Case #72: Adrenal Cystic Lymphangioma Case #73: Adrenal Hemangioma Case #74: Adrenal Ganglioneuroma Case #75: 42-Year-Old Woman with a Large Adrenal Mass   Case #76: Primary Adrenal Leiomyosarcoma Case #77: Primary Adrenal Lymphoma Case #78. 39-Year-Old Man with a Large Adrenal Mass  Case # 79: 59-Year-Old Man with Enlarging Bilateral Adrenal Masses  Case # 80: 65-Year-Old Man with Primary Adrenal Insufficiency   Case #81: 47-Year-Old Man with Primary Adrenal Insufficiency Case #82: Bilateral Adrenal Myelolipoma—Think of Congenital Adrenal Hyperplasia Case #83: A Unilateral Lipid Poor Adrenal Mass—An Atypical Presentation of Adrenal Histoplasmosis Case #84: Bilateral Macronodular Adrenal Hyperplasia (BMAH) in the Setting of Multiple Endocrine Neoplasia Type 1 Case #85: Pseudo-Adrenal Masses

Section H. Adrenal and Ovarian Hyperandrogenism Case #86: A Huge Adrenal Myelolipoma in a Patient with a Suboptimally Controlled Congenital Adrenal Hyperplasia Case #87: Balancing Glucocorticoid and Androgen Excess in Congenital Adrenal Hyperplasia Case #88: Dehydroepiandrosterone-sulfate (DHEA-S): The “Love it” or “Hate it” Hormone Case #89: Sorting out the Source of Androgen Excess in a Postmenopausal Woman with an Adrenal and an Ovarian Mass Case #90: Primary Testosterone-Secreting Adrenocortical Carcinoma in a Premenopausal Woman. Case #91: Premenopausal Woman with Testosterone-secreting Ovarian Tumor Case #92: Sorting out the Source of Androgen Excess in a Postmenopausal Woman with an Adrenal Mass Case #93: Testosterone-Secreting Benign Adrenal Adenoma in a Postmenopausal Woman

Section I. Adrenal Disorders in Pregnancy Case #94: Malignant Pheochromocytoma in Pregnancy Case #95: Catecholamine-Secreting Paraganglioma in Pregnancy Case #96: The Peripartum Diagnosis of Pheochromocytoma and a Genetic Mystery Solved Case #97. History of Pregnancy in a 41-Year-Old Woman with Undiagnosed Cushing syndrome Case #98: Pregnancy in a Patient with Primary Adrenal Insufficiency Case #99: Pregnancy in a Patient with 21-Hydroxylase Deficiency Case #100: Primary Aldosteronism in Pregnancy

"This book provides practical guidance and clinical insight for the assessment and management of a wide variety of adrenal disorders using cased-based learning. It is a helpful resource for practitioners and trainees alike, especially for reviewing rarely seen cases with expert advice."

©Doody’s Review Service, 2022, Marcelo Ramirez, M.D. (Cook County Health)