Written for fellows, practicing nephrologists, and internists who treat patients with disorders affecting the renal system, Comprehensive Clinical Nephrology, 7th Edition, offers a practical approach to this complex field, supported by underlying scientific facts and pathophysiology. World leaders in nephrology provide current information on clinical procedures and conditions, covering everything from fluid and electrolyte disorders to hypertension, diabetes, dialysis, transplantation, and more—all in a single, convenient volume.SECTION I Essential Renal Anatomy and Physiology
1 Renal Anatomy
2 Renal Physiology
SECTION II Investigation of Renal Disease
3 Assessment of Glomerular Filtration Rate
4 Urinalysis
5 Point of Care Ultrasound in Nephrology
6 Radiologic and Nuclear Imaging in Nephrology
7 Kidney Biopsy
SECTION III Fluid and Electrolyte Disorders
8 Disorders of Extracellular Volume
9 Disorders of Water Metabolism
10 Disorders of Potassium Metabolism
11 Disorders of Calcium, Phosphate, and Magnesium Metabolism
12 Normal Acid-Base Balance
13 Metabolic Acidosis
14 Metabolic Alkalosis
15 Respiratory Acidosis, Respiratory Alkalosis, and Mixed Acid-Base Disorders
SECTION IV Glomerular Disease
16 Introduction to Glomerular Disease: Clinical Presentations
17 Introduction to Glomerular Disease: Histologic Classification and Pathogenesis
18 Minimal Change Disease
19 Primary and Secondary (Nongenetic) Causes of Focal and Segmental Glomerulosclerosis
20 Inherited Causes of Nephrotic Syndrome
21 Membranous Nephropathy
22 Immunoglobulin-Mediated Glomerulonephritis With a Membranoproliferative Pattern of Injury and Cryoglobulinemic Glomerulonephritis
23 Glomerulonephritis Associated With Complement Disorders
24 Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura)
25 Anti–Glomerular Basement Membrane Disease and Goodpasture Disease
26 Renal and Systemic Vasculitis
27 Lupus Nephritis
28 Monoclonal Immunoglobulin–Related Glomerular Diseases and Renal Amyloidosis
29 Rare Glomerular Disorders
30 Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome
SECTION V Diabetic Kidney Disease
31 Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease
32 Prevention and Treatment of Diabetic Kidney Disease
33 Management of Patients With Diabetes and Chronic Kidney Disease
SECTION VI Hypertension
34 Normal Blood Pressure Control and the Evaluation of Hypertension
35 Primary Hypertension
36 Nonpharmacologic Prevention and Treatment of Hypertension
37 Pharmacologic Treatment of Hypertension
38 Evaluation and Treatment of Hypertensive Urgencies and Emergencies
39 Endocrine Causes of Hypertension: Aldosterone
40 Other Endocrine Causes of Hypertension
41 Neurogenic Hypertension, Including Hypertension Associated With Stroke or Spinal Cord Injury
42 Blood Pressure Management in the Dialysis Patient
SECTION VII Renovascular Disease
43 Renovascular Hypertension, Atherosclerotic Renal Vascular Disease, and Thromboembolic Kidney Disease
SECTION VIII Pregnancy and Renal Disease
44 Kidney Physiology and Complications in Normal Pregnancy
45 Pregnancy With Preexisting Kidney Disease
SECTION IX Hereditary and Congenital Diseases of the Kidney
46 Autosomal Dominant Polycystic Kidney Disease
47 Other Cystic Kidney Diseases
48 Alport Syndrome and Other Familial Glomerular Syndromes
49 Inherited Disorders of Sodium and Water Handling
50 Fanconi Syndrome and Other Proximal Tubule Disorders
51 Sickle Cell Diseases and the Kidney
52 Congenital Anomalies of the Kidney and Urinary Tract
SECTION X Infectious Diseases and the Kidney
53 Urinary Tract Infections in Adults
54 Tuberculosis of the Urinary Tract
55 Fungal Infections of the Urinary Tract
56 The Kidney in Schistosomiasis
57 Glomerular Diseases Associated With Infection
58 Human Immunodeficiency Virus Infection and the Kidney
59 Kidney Diseases Associated With Coronaviruses
SECTION XI Urologic Disorders
60 Nephrolithiasis and Nephrocalcinosis
61 Urinary Tract Obstruction
62 Primary Vesicoureteral Reflux and Reflux Nephropathy
63 Urologic Issues for the Nephrologist
SECTION XII Tubulointerstitial and Vascular Diseases
64 Acute Interstitial Nephritis
65 Chronic Interstitial Nephritis
66 Endemic Nephropathies
SECTION XIII Renal Disease and Cancer
67 Oncology: Kidney Disease in Cancer Patients
68 Myeloma and the Kidney
69 Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Stem Cell Transplantation
SECTION XIV Acute Kidney Injury
70 Pathophysiology and Etiology of Acute Kidney Injury
71 Acute Kidney Injury in the Tropics
72 Diagnosis and Clinical Evaluation of Acute Kidney Injury
73 Epidemiology and Prognostic Impact of Acute Kidney Injury and Acute Kidney Disease
74 Prevention and Nondialytic Management of Acute Kidney Injury
75 Extracorporeal Therapies for Acute Kidney Injury and Heart Failure
76 Hepatorenal Syndrome
SECTION XV Drug Therapy in Kidney Disease
77 Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Kidney Replacement Therapy
78 Common Issues in Prescribing in Kidney Disease and Kidney Replacement Therapy
79 Herbal and Over-the-Counter Medicines and the Kidney
SECTION XVI Chronic Kidney Disease and Uremic Syndrome
80 Epidemiology of Chronic Kidney Disease and Dialysis
81 Pathophysiology of Disease Progression in Proteinuric and Nonproteinuric Kidney Disease
82 Slowing the Progression of Kidney Disease
83 Clinical Evaluation and Management of Chronic Kidney Disease
84 Pathogenesis and Risk of Cardiovascular Disease in Chronic Kidney Disease
85 Practical Management of Cardiovascular Disease in Chronic Kidney Disease
86 Anemia in Chronic Kidney Disease
87 Other Blood and Immune Disorders in Chronic Kidney Disease
88 Bone and Mineral Disorders in Chronic Kidney Disease
89 Neurologic Complications of Chronic Kidney Disease
90 Nutrition in Chronic Kidney Disease
91 Dermatologic Manifestations of Chronic Kidney Disease
92 Acquired Cystic Kidney Disease and Malignant Neoplasms
SECTION XVII Geriatric and Palliative Nephrology
93 Geriatric Nephrology
94 Palliative Nephrology
SECTION XVIII Dialytic Therapies
95 Approach to Kidney Replacement Therapy
96 Vascular Access for Hemodialysis
97 Diagnostic and Interventional Nephrology
98 Hemodialysis
99 Hemodialysis
100 Acute Complications During Hemodialysis
101 Peritoneal Dialysis: Principles, Techniques, and Adequacy
102 Complications of Peritoneal Dialysis
103 Extracorporeal Therapies for Drug Overdose and Poisoning
104 Plasma Exchange
SECTION XIX Transplantation
105 Immunologic Principles in Kidney Transplantation
106 Immunosuppressive Medications in Kidney Transplantation
107 Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor
108 Kidney Transplantation Surgery
109 Prophylaxis and Treatment of Kidney Transplant Rejection
110 Infections and Malignancies in the Kidney Transplant Recipient
111 Cardiovascular Disease and Metabolic Abnormalities in the Kidney Transplant Recipient
112 Chronic Allograft Injury
113 Recurrent Disease in Kidney Transplantation
114 Outcomes of Kidney Transplantation: Identification, Measures, and Evaluation
Index