Hone your clinical reasoning and diagnostic skills with a new series of case-based topic-specific studies. This compilation of 20 dermatology cases from Pediatrics in Review can help increase your knowledge of skin diseases in children, encourage you to appreciate how morphology of skin disease can provide a wealth of diagnostic clues, and challenge you to think about the diverse presentations of dermatologic presentations. Cases include patients with uncommon variants of common pediatric skin conditions, moderately common conditions and mimickers, and rare rashes that can have a significant risk for systemic morbidity. Being alert for how these conditions can present can help you assess patients with similar presentations.